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Upstream Bio Inc (UPB)

Upstream Bio Inc (UPB)
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Fundamentals

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  • Market Capitalization, $K 1,669,805
  • Shares Outstanding, K 54,039
  • Annual Sales, $ 2,370 K
  • Annual Income, $ -62,810 K
  • EBIT $ -141 M
  • EBITDA $ -142 M
  • 60-Month Beta 1.90
  • Price/Sales 598.07
  • Price/Cash Flow N/A
  • Price/Book 4.60

Options Overview Details

View History
  • Implied Volatility 152.03% (-5.76%)
  • Historical Volatility 60.76%
  • IV Percentile 52%
  • IV Rank 27.15%
  • IV High 317.64% on 01/14/26
  • IV Low 90.32% on 11/19/25
  • Expected Move (DTE 35) 9.82 (31.67%)
  • Put/Call Vol Ratio 2.11
  • Today's Volume 28
  • Volume Avg (30-Day) 96
  • Put/Call OI Ratio 1.22
  • Today's Open Interest 1,966
  • Open Int (30-Day) 1,139
  • Expected Range 21.18 to 40.82

Analyst Rating / Earnings Estimates

Current Rating
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Strong Buy
Based on 9 analysts offering recommendations.
Earnings Estimates - Current Qtr 12/31/25
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  • Average Estimate -0.73
  • Number of Estimates 6
  • High Estimate -0.65
  • Low Estimate -0.90
  • Prior Year N/A
  • Growth Rate Est. (year over year) -100.07%

Price Performance

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Period Period Low Period High Performance
1-Month
25.00 +24.00%
on 01/06/26
33.68 -7.96%
on 01/14/26
+1.68 (+5.73%)
since 12/16/25
3-Month
20.65 +50.12%
on 10/17/25
33.68 -7.96%
on 01/14/26
+8.72 (+39.14%)
since 10/16/25
52-Week
5.14 +503.11%
on 04/09/25
33.68 -7.96%
on 01/14/26
+20.12 (+184.93%)
since 01/16/25

Most Recent Stories

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Upstream Bio to Present at the 44th Annual J.P. Morgan Healthcare Conference

WALTHAM, Mass., Jan. 05, 2026 (GLOBE NEWSWIRE) -- Upstream Bio, Inc. (Nasdaq: UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respiratory...

UPB : 31.00 (+0.32%)
Upstream Bio to Participate in Upcoming December Investor Conferences

WALTHAM, Mass., Nov. 25, 2025 (GLOBE NEWSWIRE) -- Upstream Bio, Inc. (Nasdaq: UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respiratory...

UPB : 31.00 (+0.32%)
Upstream Bio Reports Third Quarter 2025 Financial Results and Highlights Continued Progress

– Positive top-line results from VIBRANT Phase 2 trial of verekitug in CRSwNP reported in September showed statistically significant and clinically meaningful effects on primary and key secondary endpoints...

UPB : 31.00 (+0.32%)
Upstream Bio to Participate in Upcoming November Investor Conferences

WALTHAM, Mass., Oct. 31, 2025 (GLOBE NEWSWIRE) -- Upstream Bio, Inc. (Nasdaq: UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respiratory...

UPB : 31.00 (+0.32%)
Analysts Have Conflicting Sentiments on These Healthcare Companies: Merus (MRUS) and Upstream Bio, Inc. (UPB)

Analysts have been eager to weigh in on the Healthcare sector with new ratings on Merus (MRUS – Research Report) and Upstream Bio, Inc. (UPB – Research Report).Elevate Your Investing Strategy: Take...

UPB : 31.00 (+0.32%)
MRUS : 90.00 (-7.14%)
Upstream Bio Presents Data Showing Structural and Mechanistic Drivers of Verekitug’s Potent Pharmacodynamic Activity and Differentiated Clinical Profile at European Respiratory Society Congress

– Data show verekitug prevents TSLP binding to the TSLP receptor by occupying ligand binding sites – – Additionally, findings show that verekitug outcompetes TSLP in the presence of preformed...

UPB : 31.00 (+0.32%)
Upstream Bio to Participate in the Stifel 2025 Virtual Immunology and Inflammation Forum

WALTHAM, Mass., Sept. 09, 2025 (GLOBE NEWSWIRE) -- Upstream Bio, Inc. (Nasdaq: UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respiratory...

UPB : 31.00 (+0.32%)
Upstream Bio Reports Positive Top-Line Results from the Phase 2 VIBRANT Trial of Verekitug for the Treatment of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)

– In this 24-week study, VIBRANT met its primary endpoint, with verekitug dosed every 12 weeks leading to a statistically significant and clinically meaningful reduction from baseline in placebo-adjusted...

UPB : 31.00 (+0.32%)
Upstream Bio to Host Conference Call and Webcast to Report Top-Line Data from the Phase 2 VIBRANT Trial of Verekitug in Patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)

WALTHAM, Mass., Sept. 01, 2025 (GLOBE NEWSWIRE) -- Upstream Bio, Inc. (Nasdaq: UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respiratory...

UPB : 31.00 (+0.32%)
Upstream Bio Reports Second Quarter 2025 Financial Results and Highlights Continued Progress

– On track to report top-line data from Phase 2 trial in chronic rhinosinusitis with nasal polyps (CRSwNP) in the third quarter of 2025 – – Completed enrollment in Phase 2 trial in severe...

UPB : 31.00 (+0.32%)

Barchart Technical Opinion

The Barchart Technical Opinion rating is a 100% Buy with a Average short term outlook on maintaining the current direction.

Long term indicators fully support a continuation of the trend.

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Business Summary

Upstream Bio Inc. is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. The Company is developing verekitug, the only known antagonist currently in development which targets the receptor for thymic stromal lymphopoietin,...

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Key Turning Points

3rd Resistance Point 33.67
2nd Resistance Point 32.65
1st Resistance Point 31.83
Last Price 31.00
1st Support Level 29.99
2nd Support Level 28.97
3rd Support Level 28.15

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52-Week High 33.68
Last Price 31.00
Fibonacci 61.8% 22.78
Fibonacci 50% 19.41
Fibonacci 38.2% 16.04
52-Week Low 5.14

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