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Spruce Biosciences Inc (SPRB)

Spruce Biosciences Inc (SPRB)
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Fundamentals

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  • Market Capitalization, $K 53,220
  • Shares Outstanding, K 1,070
  • Annual Sales, $ 4,910 K
  • Annual Income, $ -53,040 K
  • EBIT $ -49 M
  • EBITDA $ -49 M
  • 60-Month Beta 3.52
  • Price/Sales 41.41
  • Price/Cash Flow N/A
  • Price/Book 4.91

Analyst Rating / Earnings Estimates

Current Rating
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Strong Buy
Based on 5 analysts offering recommendations.
Earnings Estimates - Current Qtr 12/31/25
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  • Average Estimate -12.86
  • Number of Estimates 2
  • High Estimate -12.00
  • Low Estimate -13.73
  • Prior Year -42.86
  • Growth Rate Est. (year over year) +70.00%

Price Performance

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Period Period Low Period High Performance
1-Month
48.08 +3.41%
on 02/20/26
87.40 -43.11%
on 01/22/26
-21.74 (-30.42%)
since 01/20/26
3-Month
48.08 +3.41%
on 02/20/26
112.26 -55.71%
on 11/21/25
-52.89 (-51.54%)
since 11/20/25
52-Week
4.28 +1,063.04%
on 04/29/25
240.00 -79.28%
on 10/07/25
+17.84 (+55.95%)
since 02/20/25

Most Recent Stories

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Spruce Biosciences Announces Positive Type B Meetings with U.S. FDA for TA-ERT for the Treatment of Sanfilippo Syndrome Type B (MPS IIIB)

Based on FDA Feedback, Company Continues to Advance BLA Submission for TA-ERT Using CSF HS-NRE as Reasonably Likely Surrogate Endpoint for Accelerated Approval BLA Submission...

SPRB : 49.72 (-5.51%)
Spruce Biosciences to Participate in the Oppenheimer 36th Annual Healthcare Life Sciences Conference

Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical...

SPRB : 49.72 (-5.51%)
Long-Term Data Presented at the 22nd Annual WORLDSymposium™ Highlights Tralesinidase Alfa Enzyme Replacement Therapy’s Potential as the First Disease-Modifying Treatment Option for Sanfilippo Syndrome Type B (MPS IIIB)

Treatment with Weekly TA-ERT Demonstrated Rapid and Durable Normalization of Cerebral Spinal Fluid Heparan Sulfate Non-Reducing End (CSF HS-NRE), a Surrogate Endpoint Reasonably Likely to Predict Clinical...

SPRB : 49.72 (-5.51%)
Spruce Biosciences Adds Regulatory and Clinical Development Expertise to Leadership Team

Daven Mody, Pharm.D., Appointed as Senior Vice President, Regulatory and Quality Bruno Gagnon, B.Pharm., M.Sc., Appointed as Senior Vice President, Clinical Development...

SPRB : 49.72 (-5.51%)
Spruce Biosciences Announces Data Presentations at the 22nd Annual WORLDSymposium™

Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical...

SPRB : 49.72 (-5.51%)
Harbour BioMed Acquires Common Stock in Spruce Biosciences, Deepening Strategic Collaboration

CAMBRIDGE, Mass., ROTTERDAM, Netherlands and SHANGHAI, Jan. 18, 2026 /PRNewswire/ -- Harbour BioMed (HKEX: 02142), a global biopharmaceutical company committed to the discovery and development of...

SPRB : 49.72 (-5.51%)
Spruce Biosciences Secures Up to $50 Million in Growth Capital from Avenue Capital

Initial Funding of $15 Million from the First of Four Tranches, Extending Cash Runway into 2027 Facility Will Support Advancement and Potential Launch of TA-ERT for the...

SPRB : 49.72 (-5.51%)
Spruce Biosciences Appoints Proven Pharmaceutical Commercial Leader Keli Walbert to Board of Directors

Keli Walbert brings decades of commercial leadership experience and a proven track record of successful product launches in rare disease

SPRB : 49.72 (-5.51%)
Spruce Biosciences Reports Third Quarter 2025 Financial Results and Provides Corporate Updates

Granted Breakthrough Therapy Designation for Tralesinidase Alfa Enzyme Replacement Therapy (TA-ERT) for the Treatment of Sanfillipo Syndrome Type B (MPS IIIB) Biologics...

SPRB : 49.72 (-5.51%)
Spruce Biosciences Secures $50 Million Investment Deal

Elevate Your Investing Strategy: Take advantage of TipRanks Premium at 50% off! Unlock powerful investing tools, advanced data, and expert analyst insights to help you invest with confidence. Spruce Biosciences...

SPRB : 49.72 (-5.51%)

Business Summary

Spruce Biosciences Inc. is a biopharmaceutical company. It focuses on developing and commercializing novel therapies for rare endocrine disorders. The company develops tildacerfont, an non-steroidal therapy which are in clinical stage. Spruce Biosciences Inc. is based in Daly City, California.

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Key Turning Points

3rd Resistance Point 59.49
2nd Resistance Point 56.88
1st Resistance Point 53.30
Last Price 49.72
1st Support Level 47.11
2nd Support Level 44.50
3rd Support Level 40.92

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52-Week High 240.00
Fibonacci 61.8% 149.95
Fibonacci 50% 122.14
Fibonacci 38.2% 94.32
Last Price 49.72
52-Week Low 4.28

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