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Denali Therapeutics Inc (DNLI)

Denali Therapeutics Inc (DNLI)
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Denali Therapeutics, a biopharmaceutical company, is developing a wide and innovative portfolio of targeted therapeutic candidates, which are engineered to cross the blood-brain barrier for neurodegenerative diseases. It has 5 clinical-stage programs, a leucine-rich repeat kinase 2 inhibitor program partnered with Biogen to address Parkinson's disease, an eukaryotic translation initiation factor 2B activator program to address diseases such as amyotrophic lateral sclerosis and frontotemporal dementia (FTD), the ETV:IDS program, which utilizes the company's enzyme transport vehicle technology, and is designed to restore iduronate 2-sulfatase and reduce glycosaminoglycans, in patients with mucopolysaccharidosis II, and two separate receptor interacting serine/threonine protein kinase 1 inhibitor programs, both partnered with Sanofi. It also has a collaboration and option agreement with Takeda Pharmaceutical Co. Ltd. Takeda has exercised its option to jointly develop and commercialize DNL593 with the company.

Fiscal Year End Date: 12/31

(Values in U.S. Thousands) Dec, 2024 Dec, 2023 Dec, 2022 Dec, 2021 Dec, 2020
Sales 0 330,530 108,460 48,660 335,660
Sales Growth -100.00% +204.75% +122.89% -85.50% +1,158.10%
Net Income -422,770 -145,220 -325,990 -290,580 71,140
Net Income Growth -191.12% +55.45% -12.19% -508.46% +136.00%
(Values in U.S. Thousands) Dec, 2024 Dec, 2023 Dec, 2022 Dec, 2021 Dec, 2020
Total Assets 1,374,180 1,153,920 1,460,240 1,404,160 1,604,280
Total Assets Growth +19.09% -20.98% +3.99% -12.47% +189.98%
Total Liabilities 144,500 122,960 417,810 441,870 453,750
Total Liabilities Growth +17.52% -70.57% -5.45% -2.62% +186.57%
(Values in U.S. Thousands) Dec, 2024 Dec, 2023 Dec, 2022 Dec, 2021 Dec, 2020
Operating Cash Flow -347,690 -357,990 -244,720 -211,390 416,150
Operating Cash Flow Growth +2.88% -46.29% -15.77% -150.80% +374.54%
Net Cash Flow 47,850 -90,860 -75,430 -213,670 427,700
Change in Net Cash Flow +152.66% -20.46% +64.70% -149.96% +18,256.22%
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