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Denali Therapeutics Inc (DNLI)

Denali Therapeutics Inc (DNLI)
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Fundamentals

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  • Market Capitalization, $K 4,058,215
  • Shares Outstanding, K 158,710
  • Annual Sales, $ 0 K
  • Annual Income, $ -512,540 K
  • EBIT $ -547 M
  • EBITDA $ -546 M
  • 60-Month Beta 1.03
  • Price/Sales N/A
  • Price/Cash Flow N/A
  • Price/Book 4.24

Options Overview Details

View History
  • Implied Volatility 98.28% (+23.98%)
  • Historical Volatility 48.01%
  • IV Percentile 79%
  • IV Rank 43.42%
  • IV High 155.38% on 11/13/25
  • IV Low 54.46% on 08/18/25
  • Expected Move (DTE 20) 1.70 (6.65%)
  • Put/Call Vol Ratio 0.45
  • Today's Volume 369
  • Volume Avg (30-Day) 1,189
  • Put/Call OI Ratio 0.91
  • Today's Open Interest 12,523
  • Open Int (30-Day) 12,252
  • Expected Range 23.87 to 27.27

Analyst Rating / Earnings Estimates

Current Rating
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Strong Buy
Based on 19 analysts offering recommendations.
Earnings Estimates - Current Qtr 06/30/26
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  • Average Estimate $-0.73
  • Number of Estimates 9
  • High Estimate $-0.67
  • Low Estimate $-0.89
  • Prior Year $-0.72
  • Growth Rate Est. (year over year) -1.39%

Price Performance

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Period Period Low Period High Performance
1-Month
18.92 +35.15%
on 06/02/26
25.97 -1.52%
on 06/25/26
+6.19 (+31.94%)
since 05/26/26
3-Month
17.71 +44.38%
on 05/19/26
25.97 -1.52%
on 06/25/26
+5.83 (+29.57%)
since 03/26/26
52-Week
12.58 +103.26%
on 09/22/25
25.97 -1.52%
on 06/25/26
+11.08 (+76.47%)
since 06/26/25

Most Recent Stories

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Denali Therapeutics Enters Agreement to Sell Rare Pediatric Disease Priority Review Voucher for $195 Million

Proceeds from transaction to support advancement of Denali’s broad TransportVehicle™-enabled clinical portfolio for lysosomal storage disorders and neurodegenerative diseases Denali was awarded...

DNLI : 25.57 (+3.40%)
Stocks Settle Higher on Iran Peace Hopes and Tech Strength

The S&P 500 Index ($SPX ) (SPY ) on Friday closed up +0.37%, the Dow Jones Industrial Average ($DOWI ) (DIA ) closed up +0.58%, and the Nasdaq 100 Index ($IUXX ) (QQQ ) closed up +0.42%. June E-mini S&P...

AMAT : 626.84 (-6.16%)
INTU : 267.72 (+4.96%)
ADI : 386.91 (-7.42%)
DDOG : 239.77 (+8.52%)
MRK : 128.66 (+2.56%)
TXN : 285.42 (-8.46%)
$IUXX : 29,118.24 (-1.09%)
COIN : 149.06 (+4.59%)
ASML : 1,794.62 (-2.53%)
ZNU26 : 110-085s (+0.16%)
ESU26 : 7,401.75s (-0.29%)
QCOM : 189.39 (-7.57%)
Stocks Climb on US-Iran Peace Hopes and Strength in Chipmakers

The S&P 500 Index ($SPX ) (SPY ) today is up +0.50%, the Dow Jones Industrial Average ($DOWI ) (DIA ) is up +0.63%, and the Nasdaq 100 Index ($IUXX ) (QQQ ) is up +0.73%. June E-mini S&P futures (ESM26...

AMAT : 626.84 (-6.16%)
INTU : 267.72 (+4.96%)
ADI : 386.91 (-7.42%)
DDOG : 239.77 (+8.52%)
MRK : 128.66 (+2.56%)
TXN : 285.42 (-8.46%)
$IUXX : 29,118.24 (-1.09%)
ASML : 1,794.62 (-2.53%)
ZNU26 : 110-085s (+0.16%)
ESU26 : 7,401.75s (-0.29%)
QCOM : 189.39 (-7.57%)
IBM : 271.63 (+5.17%)
Stocks Supported by US-Iran Peace Deal Optimism

The S&P 500 Index ($SPX ) (SPY ) today is up +0.54%, the Dow Jones Industrial Average ($DOWI ) (DIA ) is up +0.70%, and the Nasdaq 100 Index ($IUXX ) (QQQ ) is up +0.53%. June E-mini S&P futures (ESM26...

AMAT : 626.84 (-6.16%)
INTU : 267.72 (+4.96%)
ADI : 386.91 (-7.42%)
DDOG : 239.77 (+8.52%)
MRK : 128.66 (+2.56%)
TXN : 285.42 (-8.46%)
$IUXX : 29,118.24 (-1.09%)
ASML : 1,794.62 (-2.53%)
ZNU26 : 110-085s (+0.16%)
MSFT : 372.97 (+5.71%)
ESU26 : 7,401.75s (-0.29%)
QCOM : 189.39 (-7.57%)
Biogen and Denali Therapeutics Provide Update on Phase 2b LUMA Study of BIIB122 (DNL151) in Early-Stage Parkinson’s Disease

The Phase 2b LUMA study of BIIB122 in early-stage Parkinson’s disease did not meet its primary or secondary endpoints  Based on data from the Phase 2b LUMA study, Biogen and Denali will discontinue...

DNLI : 25.57 (+3.40%)
BIIB : 216.03 (+6.97%)
Denali Therapeutics Says AVLAYAH Launch Ahead of Expectations After Hunter Syndrome Approval

Denali Therapeutics (NASDAQ:DNLI) is seeing early commercial interest for its first approved drug, AVLAYAH, following its March 24 accelerated approval for Hunter syndrome, Chief Operating Officer and...

DNLI : 25.57 (+3.40%)
Denali Therapeutics Reports First Quarter 2026 Financial Results and Business Highlights

FDA approved AVLAYAHâ„¢ (tividenofusp alfa-eknm) for treatment of Hunter syndrome (MPS II) and as first medicine to leverage transferrin receptor to cross blood-brain barrier AVLAYAH launched in U.S....

DNLI : 25.57 (+3.40%)
Denali's First Commercial Quarter Will Show Whether Hunter Syndrome Launch Mechanics Actually Work

Barchart Research What to Expect from DNLI Earnings DNLI Generated May 4, 2026 Current Price $18.67 EPS Estimate $$-0.73 Consensus Rating Strong Buy Average Move 5.31% Denali's First Commercial Quarter...

DNLI : 25.57 (+3.40%)
Denali Therapeutics Regains Full Rights to Investigational Therapy DNL593 (PTV:PGRN) for GRN-related Frontotemporal Dementia (FTD-GRN)

Denali plans to continue clinical development of DNL593, which is designed to deliver progranulin to the brain using TransportVehicleâ„¢ technology Results from ongoing Phase 1/2 study in patients with...

DNLI : 25.57 (+3.40%)
Denali Therapeutics Announces U.S. FDA Approval of AVLAYAHâ„¢ (tividenofusp alfa-eknm) for Treatment of Hunter Syndrome (MPS II)

First new FDA-approved treatment option in nearly 20 years for families living with this rare lysosomal storage disease First FDA-approved medicine in emerging new class of biotherapeutics that leverage...

DNLI : 25.57 (+3.40%)

Barchart Technical Opinion

The Barchart Technical Opinion rating is a 100% Buy and ranks in the Top 1% of all short term signal directions.

Long term indicators fully support a continuation of the trend.

Relative Strength is above 70%. The market is in overbought territory. Watch for a potential trend reversal.

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Business Summary

Denali Therapeutics, a biopharmaceutical company, is developing a wide and innovative portfolio of targeted therapeutic candidates, which are engineered to cross the blood-brain barrier for neurodegenerative diseases. It has 5 clinical-stage programs, a leucine-rich repeat kinase 2 inhibitor program...

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Key Turning Points

3rd Resistance Point 27.01
2nd Resistance Point 26.36
1st Resistance Point 25.96
Last Price 25.57
1st Support Level 24.91
2nd Support Level 24.26
3rd Support Level 23.86

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52-Week High 25.97
Last Price 25.57
Fibonacci 61.8% 20.85
Fibonacci 50% 19.27
Fibonacci 38.2% 17.69
52-Week Low 12.58

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