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Upstream Bio Inc (UPB)

Upstream Bio Inc (UPB)
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Fundamentals

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  • Market Capitalization, $K 1,499,582
  • Shares Outstanding, K 54,039
  • Annual Sales, $ 2,370 K
  • Annual Income, $ -62,810 K
  • EBIT $ -141 M
  • EBITDA $ -142 M
  • 60-Month Beta 1.83
  • Price/Sales 632.51
  • Price/Cash Flow N/A
  • Price/Book 3.95

Options Overview Details

View History
  • Implied Volatility 143.35% (+5.41%)
  • Historical Volatility 72.63%
  • IV Percentile 54%
  • IV Rank 46.06%
  • IV High 205.46% on 09/24/25
  • IV Low 90.32% on 11/19/25
  • Expected Move (DTE 12) 1.36 (4.90%)
  • Put/Call Vol Ratio 0.08
  • Today's Volume 27
  • Volume Avg (30-Day) 18
  • Put/Call OI Ratio 0.75
  • Today's Open Interest 775
  • Open Int (30-Day) 2,910
  • Expected Range 26.39 to 29.11

Analyst Rating / Earnings Estimates

Current Rating
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Strong Buy
Based on 8 analysts offering recommendations.
Earnings Estimates - Current Qtr 12/31/25
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  • Average Estimate -0.73
  • Number of Estimates 6
  • High Estimate -0.65
  • Low Estimate -0.90
  • Prior Year N/A
  • Growth Rate Est. (year over year) -100.07%

Price Performance

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Period Period Low Period High Performance
1-Month
21.98 +26.25%
on 11/07/25
33.00 -15.91%
on 11/26/25
+3.78 (+15.77%)
since 11/05/25
3-Month
15.55 +78.46%
on 09/17/25
33.00 -15.91%
on 11/26/25
+7.78 (+38.96%)
since 09/05/25
52-Week
5.14 +439.88%
on 04/09/25
33.00 -15.91%
on 11/26/25
+5.75 (+26.14%)
since 12/05/24

Most Recent Stories

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Upstream Bio to Participate in Upcoming December Investor Conferences

WALTHAM, Mass., Nov. 25, 2025 (GLOBE NEWSWIRE) -- Upstream Bio, Inc. (Nasdaq: UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respiratory...

UPB : 27.75 (+0.04%)
Upstream Bio Reports Third Quarter 2025 Financial Results and Highlights Continued Progress

– Positive top-line results from VIBRANT Phase 2 trial of verekitug in CRSwNP reported in September showed statistically significant and clinically meaningful effects on primary and key secondary endpoints...

UPB : 27.75 (+0.04%)
Upstream Bio to Participate in Upcoming November Investor Conferences

WALTHAM, Mass., Oct. 31, 2025 (GLOBE NEWSWIRE) -- Upstream Bio, Inc. (Nasdaq: UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respiratory...

UPB : 27.75 (+0.04%)
Analysts Have Conflicting Sentiments on These Healthcare Companies: Merus (MRUS) and Upstream Bio, Inc. (UPB)

Analysts have been eager to weigh in on the Healthcare sector with new ratings on Merus (MRUS – Research Report) and Upstream Bio, Inc. (UPB – Research Report).Elevate Your Investing Strategy: Take...

UPB : 27.75 (+0.04%)
MRUS : 96.14 (-0.08%)
Upstream Bio Presents Data Showing Structural and Mechanistic Drivers of Verekitug’s Potent Pharmacodynamic Activity and Differentiated Clinical Profile at European Respiratory Society Congress

– Data show verekitug prevents TSLP binding to the TSLP receptor by occupying ligand binding sites – – Additionally, findings show that verekitug outcompetes TSLP in the presence of preformed...

UPB : 27.75 (+0.04%)
Upstream Bio to Participate in the Stifel 2025 Virtual Immunology and Inflammation Forum

WALTHAM, Mass., Sept. 09, 2025 (GLOBE NEWSWIRE) -- Upstream Bio, Inc. (Nasdaq: UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respiratory...

UPB : 27.75 (+0.04%)
Upstream Bio Reports Positive Top-Line Results from the Phase 2 VIBRANT Trial of Verekitug for the Treatment of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)

– In this 24-week study, VIBRANT met its primary endpoint, with verekitug dosed every 12 weeks leading to a statistically significant and clinically meaningful reduction from baseline in placebo-adjusted...

UPB : 27.75 (+0.04%)
Upstream Bio to Host Conference Call and Webcast to Report Top-Line Data from the Phase 2 VIBRANT Trial of Verekitug in Patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)

WALTHAM, Mass., Sept. 01, 2025 (GLOBE NEWSWIRE) -- Upstream Bio, Inc. (Nasdaq: UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respiratory...

UPB : 27.75 (+0.04%)
Upstream Bio Reports Second Quarter 2025 Financial Results and Highlights Continued Progress

– On track to report top-line data from Phase 2 trial in chronic rhinosinusitis with nasal polyps (CRSwNP) in the third quarter of 2025 – – Completed enrollment in Phase 2 trial in severe...

UPB : 27.75 (+0.04%)
Upstream Bio Announces First Patient Dosed in Phase 2 Clinical Trial of Verekitug in Chronic Obstructive Pulmonary Disease (COPD)

UPB : 27.75 (+0.04%)

Barchart Technical Opinion

The Barchart Technical Opinion rating is a 100% Buy with a Strongest short term outlook on maintaining the current direction.

Long term indicators fully support a continuation of the trend.

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Business Summary

Upstream Bio Inc. is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. The Company is developing verekitug, the only known antagonist currently in development which targets the receptor for thymic stromal lymphopoietin,...

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Key Turning Points

3rd Resistance Point 29.87
2nd Resistance Point 29.15
1st Resistance Point 28.45
Last Price 27.75
1st Support Level 27.02
2nd Support Level 26.30
3rd Support Level 25.60

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52-Week High 33.00
Last Price 27.75
Fibonacci 61.8% 22.36
Fibonacci 50% 19.07
Fibonacci 38.2% 15.78
52-Week Low 5.14

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